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The prevalence of the ischemic stroke was OR 1.39, which was significantly higher in the AI group than tamoxifen (95% CI 1.07–1.81). In addition, the heart-related cardiovascular events, myocardial infarction (OR 1.30, 95% CI 0.88–1.93), and heart failure (OR 1.20, 95% CI 0.78–1.86) occurred relatively more frequently in the AI group but were not statistically www.thedatingpros.com/heatedaffairs-review significant. Meanwhile, the occurrence of other cardiovascular events did not show a significant difference between the AI and the tamoxifen group. Pooled forest plots and forest plots of each outcome are presented in Figure 3 and Supplementary Figure S2, respectively. Classification by country was based on the country where the research was mainly conducted.

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Furthermore, an awareness of better survival patterns amongst HPV-related OPSCC patients boosted interest in systemic treatment de-escalation following mini-invasive trans-oral techniques . However, literature data on trans-oral surgery in advanced stages is limited, due to difficult cancer exposure and possible insufficient surgical radicality with positive resection margins . Thirdly, a single strategy was often used to protect Zn anodes, resulting in an uncomprehensive development, making ZIBs difficult to implement. Also, the exploration of the 2D materials in Zn anodes is mostly focused on the coin cells, which deviates from actual needs like large capacity and flexible batteries. In addition, the mass production of 2D materials-based anodes on a large scale remains challenging.

This method can also be used to introduce other functional materials into the protective layer to further improve battery performance. For example, Feng et al. introduced chitosan into MXene film by simply mixing these two dispersion liquids and coating them on the Zn foil . Chitosan has hydroxyl and amine groups which can be served as coordination sites for transition metals. Meanwhile, electrostatic interaction can self-assemble this positively charged natural bio-polysaccharide on the surface of negatively charged MXene nanosheets.

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Uemura, K.; Takahashi, H.; Mino, K.; Ota, T.; Shichi, S. A Case of Surgical Resection of a Combined Hepatocellular and Cholangiocarcinoma with Hemobilia from Intraductal Tumor Thrombus. Javle, M.; Churi, C.; Kang, H.C.; Shroff, R.; Janku, F.; Surapaneni, R.; Zuo, M.; Barrera, C.; Alshamsi, H.; Krishnan, S.; et al. HER2/neu-directed therapy for biliary tract cancer. Su, Y.L.; Ng, C.T.; Jan, Y.H.; Hsieh, Y.L.; Wu, C.L.; Tan, K.T. Remarkable Response to Olaparib in a Patient with Combined Hepatocellular-Cholangiocarcinoma Harboring a Biallelic BRCA2 Mutation.

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To date, two meta-studies have been conducted on whether AI increases CVD in breast cancer patients . However, the results of the two meta-analyses were inconsistent. In a meta-analysis published in 2017 , AI increased CVD by 19% compared to the control group, but in a meta-analysis published in 2019 , the increase in CVD in the AI group compared to the control group was not significant.

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In addition to these retrospective observational studies, several case reports have described a potential benefit of sorafenib, lenvatinib, checkpoint inhibitors, or different chemotherapy regimens. Tham, T.; Wotman, M.; Roche, A.; Kraus, D.; Costantino, P. The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma. Gross’s study has shown that OPSCC pT4 patients were more likely to have worse swallow function than pT3 ones, in line with other previous studies . The study also showed that the risk of dysphagia is three times higher in patients undergoing surgery with ≥50% resection of the base of tongue . Although transoral approaches significantly reduce these disadvantages compared to traditional open surgery, literature data comparing treatment approaches for advanced-stage tumours are limited . The surgical techniques applied in advanced OPSCC stages have also changed over time .

Therefore, they obtained GDY film with homogenous morphology and an average thickness of 1–2 nm on the surface of the metal substrate and successfully avoided the formation of Zn dendrites due to the high electrical conductivity and uniform pore size. Zn anodes protective layers fabricated by graphene and its derivates can be considered a kind of SEI to some extent, dealing with their 2D feature , high stability, hydrophilicity, zincophilicity, and other characteristics. Their function of inhibiting dendrite growth and side reactions has already been employed in research for years. Wei and co-workers first utilized rGO in both ZIB anodes and cathodes due to its high electronic conductivity and excellent mechanical properties . The rGO protective layer can effectively inhibit the Zn dendrite formation by enabling a uniform charge distribution and providing fast and effective electron transfer channels. Besides, the rGO layer restrains the dendrite formation through its mechanical properties while strongly attached to the Zn metal surface.

Simultaneously, PG can enhance charge transfer and then facilitate the electrodeposition kinetics of zinc, and the unique hexagonal lattice structure can promote horizontally aligned zinc deposits. Aside from pure graphene, researchers also developed modified graphene for Zn anode protection, such as graphene oxide containing oxygen functional groups and nitrogen-doped graphene oxide embedded by N elements. These derivates utilize their hydrophilicity, zincophilicity or size effect to facilitate rapid and smooth deposition of Zn2+ . This section will summarize the Zn anode protective methods, including surface engineering, host architecture, separator modification, and electrolyte additives, through the application of graphene and their derivates (Fig.4). Because of these unique properties, graphene has great application potential in many fields, especially for energy storage like ZIBs. These properties render graphene an ideal material applied for the protection of the Zn metal anode by inhibiting the formation and growth of dendrites.